Curriculums and credits

1. Introduction to Integrative Bioscience (Integrated Bioscience Education Program)
2. Structual Biomolecular Science (Dept. Struct. Mol. Sci.)
3. Bioinformatics Practical Course (Dept. Basic Biol.)
4. Imaging Science (Dept. Physiol. Sci.)
5. Integrative Bioscience Series (Integrated Bioscience Education Program)
6. Introduction to Biomolecular Simulation (Dept. Struct. Mol. Sci. & Dept. Fuct. Mol. Sci.)
7. Integrative Evolutionary Studies (Dept. Evolutionary Studies of Biosystems)
8. Molecular Cell BiologyⅡ (Dept. Basic Biol., & Dept. Genetics)
9. Fundamentals of Biomolecular Science (Dept. Struct. Mol. Sci., & Dept. Funct. Mol. Sci.)
10. Bioinformatics (Dept. Gentics., Dept. Evolutionary Studies of Biosystems & Dept. Infomatics)
11. Origin of Life (Dept. Basic Biol., Dept. Gentics, & Dept. Evolutionary Studies of Biosystems)
12. Mechano-systems Biology (Dept. Struct. Mol. Sci., Dept. Basic Biol., & Dept. Physiol.)
13. Quantitative Biology (Dept. Statistical Sci., Dept. Basic Biol., & Dept. Genetics)
14. Integrative Bioscience (Integrative Bioscience Education Program)
*Courses indicated in bold-face will be offered this year.

1. Introduction to Integrative Bioscience

【fiscal year 2013】
● Course title
Introduction to Integrative Bioscience
 
● Credit
1
 
● Lecturer
Toshitaka Fujisawa (CPIS, SOKENDAI)

● Place
Yamate campus, building 3, 9F Seminar room B 
The lectures are delivered to remote campuses by remote lecture delivering systems.
 
●Contents of subject
The educational program for Integrative bioscience will be introduced, overviewing contemporary bioscience and discussing the features and necessity of the Integrative bioscience.
 
●Course objectives
First, the educational program for Integrative bioscience will be introduced. Then, driving forces for rapid development of biology are reviewed from a historical point of view, and the features of contemporary life science are overviewed. Based on these reviews what the Integrative bioscience is and why it is necessary are discussed5/1, 8, 1. Particularly, it is emphasized that a large volume of information on sequences and structures of genome, RNA, proteins, sugars, metabolites etc. and that of spacio-temporal expression of these molecules are integrated to understand their meaning at a cell, tissue, organ or organism level and to unravel the mechanisms of high order biological functions, diseases, environmental responses etc.  

●Schedule
For the fiscal year 2013
 4/25,5/9,16,23,6/6,13,20,27 Thursday 10:00 -12:00
 
●Contents
(1) Introduction of the educational program for Integrative bioscience   
(2) Driving forces for biology                                                              
(3) Characteristics of contemporary bioscience 1                                  
(4) Characteristics of contemporary bioscience 2                                  
(5) Characteristics of contemporary bioscience 3                                                  
(6) Characteristics of contemporary bioscience 4                                                     
(7) What is Integrative bioscience ?                                                    
(8) Significance of Integrative bioscience                                             
 
●Lecture materials and readings:
No specific textbook is used. References will be introduced in the lecture when necessary. 
 
● Grades
The grade is determined by reports/homeworks and attendance at the lectures. 60 points are necessary to get the credit.

☆For the details of schedule, please refer "Schedule of the classes".
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⇒ Syllabus PDFPDF

2. Structual Biomolecular Science

【fiscal year 2013】
●Course title
★Structual Biomolecular Science (Dept. Struct. Mol. Sci.) fiscal year 2013 
   Functional Biomolecular Science  (Dept. Funct. Mol. Sci.) fiscal year 2014

 ●Credit


●Appropriate grade level and Eligible Departments  1st-5th grades

●Lecturer(s)
 Prof. Shigetoshi Aono (IMS Dept. of Life and Coordination-Complex Molecular Science)
 Assoc. Prof. Yuji Furutani (IMS Dept. of Life and Coordination-Complex Molecular Science)

●Schedule
the fiscal year 2013 12/17,18,19,20 (10:30-12:30,13:30-15:30)

1.Metals in biology
2.Transcriptional regulation in response to environmental conditions
3.Biogenesis of metalloproteins and translational regulation
4.Homeostasis of transition metal ions in cells
5.Biological signal transduction involving metalloproteins
6.Biological energy metabolism
7.Biological and artificial membranes
8.Structure and function of membrane proteins
9.Signal perception: Bioelectrical signal, Molecular mechanisms of ion channel, transporter, and light receptors
10.Motion of proteins: Molecular motor, ATP synthase
11.Recent topics

●Place
Myodaiji Research Office 301,IMS  
The lectures are delivered to remote campuses by remote lecture delivering systems.

●Prerequisites and Styles:
●Course objectives:
To get basic knowledge about life sciences and to understand the molecular mechanisms of biological processes.
 
●Contents:
The molecular mechanisms of various biological processes will be lectured in this course. Especially, the molecular mechanisms of the following topics will be provided: DNA replication, transcription and translation of DNA, cellular homeostasis, biological energy conversion such as respiration and photosynthesis, sensory receptors, bioelectronics in a neuron, and some recent research topics.
 
●Lecture materials and readings:
1.Principles of Bioinorganic Chemistry, Stephen J. Lippard, Jeremy M. Berg, University Science Book
2.Membrane Structural Biology With Biochemical and Biophyscial Foundations, Mary Luckey, Cambridge University Press
 
●Grades:
To earn the credit, attendance of more than 60% of all the lectures and submission of a report on the subject given in the lecture are required. The grade will be estimated based upon the attendance and the report. The credit will be awarded if the grade is 60/100 or higher.

☆For the details of schedule, please refer "Schedule of the classes".
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⇒ Syllabus PDFPDF

3. Bioinformatics Practical Course

Fiscal year 2013】
●Course title
 Bioinformatics Practical Course Lecture and tutorial
*This subject is the same as "Bioinformatics Practical Course" in The Sokendai Brain Science Joint Program.

●Credit
One credit

●Appropriate grade level and Eligible Departments
All Departments

●Lecturer(s)
Satoru Kobayashi (NIBB)
Shuji Shigenobu (NIBB)

●Schedule
 schedule for the second semester in 2013
   9:00-10:30 and 11:00-12:30 on Thursday  (10/24,11/7,11/14,11/21) 
(1) Introduction to Genomics Shuji Shigenobu (NIBB)

(2) Biological sequence analysis 1 Shuji Shigenobu (NIBB)

(3) Biological sequence analysis 2 Shuji Shigenobu (NIBB)

(4) Lab tutorial 1(This is NOT delivered by the remote lecture system) Shuji Shigenobu (NIBB)

(5) Gene expression and transcriptome Shuji Shigenobu (NIBB)

(6) Proteomics and functional genomics Shuji Shigenobu (NIBB)

(7) Lab tutorial 2 (Biological database) Shuji Shigenobu (NIBB)

(8) Current topics on genome Shuji Shigenobu (NIBB)

●Place
    Yamate campus, building 3, 9F Seminar room B [Oct 24, Nov 14]
    1F seminar room 1 in National Institute of Basic Biology [Nov 7, Nov 21] 

●Course objectives
To understand basic principles in biological sequence analyses.
To obtain basic skills in genomic and proteomic analyses.
To understand current topics and future directions in bioinformatics.

●Contents
Basic knowledge and skills in analyses of genome, proteome, and transcriptome will be introduced in lectures and tutorials.

●Grades
Synthetically judged by sufficient attendance to the lectures and a reporting assignment.

●Prerequisites and Styles
No particular background knowledge is required.

●Lecture materials and readings
Laptop computers will be ready and useful database will be introduced on site for the tutorial.

☆For the details of schedule, please refer "Schedule of the classes".
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⇒ Syllabus PDFPDF

4. Imaging Science

【Fiscal year 2013】
● Course title
Imaging Science
 
● Course objectives
We are now enjoying various imaging techniques in the cutting edge of biological and medical sciences. The well known from old is microscopic techniques and nowadays MRI, PET and MEG are popular imaging tools. Imaging science is a novel discipline trying to integrate the old and the new. It consists of three categories, hardware tools to generate primary data, software tools to digitally process the primary data and imaging analysis to quantitatively analyze imaging digital data. In this lecture, 3D imaging and quantitative image analysis are in a particular focus. The former includes the theoretical background of 3D imaging and its practical applications with electron and light microscopy. The latter includes a novel quantitative image analysis based on various numerical algorithms.
This lecture series welcome students who are eager to learn a basic theory to practical applications in a field of imaging science.
 
● Credit
 1
 
● Appropriate grade level and Eligible Departments:
 1st-5th grades
 
●Lecturers
 Kuniaki Nagayama (NIPS)
   Naofumi Iwama (NINS)
   Kazuyoshi Murata (Dept. Physiol. Sci. )
   Shigenori Nonaka (Dept. Basic Biol. )
   Hideji Murakoshi (Dept. Physiol. Sci.)
 Yoshitaka Kimori (Centr. Novel Sci. Initiatives)
 
●Schedule
 Feburaru 18 (Tue), 19 (Wed), 2014
 
● Place
  Yamate campus, building 3, 9F Seminar room B
   (19 am : Yamate campus, building 3, 9F Seminar room A)
 
●Contents:
  TBD
 
● Grades
Sufficient attendance to the lecture and a score of some reports
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⇒ Syllabus PDFPDF

5. Integrative Bioscience Series

【fiscal year 2013】
●Course title
Integrative Bioscience Series
 
●Credit
1
 
●Appropriate grade level and Eligible Departments
1st-5th grades
 
●Lecturers
Toshitaka Fujisawa (CPIS, SOKENDAI)
Tatsuya Ohota(Dept. Evolutional Studies Biosystems)
Masaki Sasai (Nagoya University )
Kazuhiro Ikenaka (Dept. Physiol. Sci. )
Masanao Sato (Dept. Basic. Sci.)
Yuji Furutani (Dept. Funct. Sci.)
Daiki Kitagawa (Dept. Genetics)
Syuhei Mano (Dept. Statistical Sci.)
 
●Schedule
2013:July 1  and 8 

  July 1 (Mon) 
 9:00-10:30  "Molecular evolution of biosystems - immune system as an example - "  Tatsuya Ohota 
                      (Hayama Campus ,TV Conference Room, Library Building 3F)
10:30-12:00  "Landscape theories in bioscience"    Masaki Sasai
                    (Yamate campus, building 3, 9F Seminar room B)
13:00-14:30   “Function and diseases of glial cells”   Kazuhiro Ikenaka
                    (Yamate campus, building 3, 9F Seminar room B)
14:30-16:00 "Network Biology: a new perspective towards understanding complex biological   
                      systems"   Masanao Sato(Yamate campus, building 3, 9F Seminar room B)
July 8 (Mon)
 9:00-10:30   Yuji Furutani (Yamate campus, building 3, 9F Seminar room B)
10:30-12:00  "Cell biology using a combination of multi-disciplinary approaches"   Daiki Kitagawa  
                     (3F seminar room of the library in National Institute of Genetics)
13:00-14:00   “Inference about genome diversity by stochastic modeling”   Syuhei Mano   
                    (The Institute of Statistical Mathematics ,2F Seminar room1 D222)
14:00-15:00 "Summary of Integrative Bioscience Series"     Toshitaka Fujisawa (CPIS, SOKENDAI)

 The lectures are delivered to remote campuses by remote lecture delivering systems.
 
●Place
 Yamate campus, building 3, 9F Seminar room B
 3F seminar room of the library in National Institute of Genetics
 Hayama Campus ,TV Conference Room, Library Building 3F
 The Institute of Statistical Mathematics ,2F Seminar room1 (D222)
 
●Course objectives
To learn biological processes at various levels, covering molecular, cellular and individual processes, with broader perspective in an integrative manner, seven departments (Departments of Structural Molecular Science, Functional Molecular Science, Basic Biology, Physiological Sciences, Genetics, Evolutional Studies of Biosystems, and Statistical Science), which participate in the Integrative Bioscience Education Program, offer a series of the following lectures in an understandable manner for students in the first and second years. 
 
●Contents:
 TBD
 
●Grades
Sufficient attendance to the lecture and a score of some reports

☆For the details of schedule , please refer "Schedule of the classes".
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⇒ Syllabus PDFPDF

6. Introduction to Biomolecular Simulation

【fiscal year 2013】
● Course title
Introduction to Biomolecular Simulation

● Course objectives
Basic theories and computational methods for molecular simulations for biomoleculs will be introduced.  For example, basic and various advanced methodologies for molecular simulations as well as fundamentals of analytical mechanics and statistical mechanics will be lectured.

● Credit  
1 credit

● Appropriate grade level and Eligible Departments
1st-5th grades

● Lecturers
Prof Shinji Saito (IMS )
Assoc. Prof. Hisashi Okumura(IMS)

● Place
Myodaiji Research Office 301,IMS
The lectures are delivered to remote campuses by remote lecture delivering systems.

● Schedule
schedule for the second semester in 2013:December 10  and 12
The lectures are delivered to remote campuses by remote lecture delivering systems.


●Grades
Sufficient attendance to the lecture and a score of some reports

☆For the details of schedule, please refer "Schedule of the classes".
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⇒ Syllabus PDFPDF

7. Integrative Evolutionary Studies

【fiscal year 2013】
●Course title
Integrative Evolutionary Studies
 
●Credit  
  2 credits

●Appropriate grade level and Eligible Departments
 1st-5th grades

●Lecturer:
Yoko Satta (Dept. Evolutionary Studies of Biosystems)

●Schedule:
2014/1/8 (10:30-12:00)・1/9 (15:00-18:00, )・
2014/1/29・30・2/5・6(10:30-12:00, 13:00-14:30,14:30-16:00)

●Place: Hayama campus, Library (3F) TV conference room
 
●Contents of subject:
Biosystems on the earth can be classified into systems with different levels of complexity, from a cell to society. This course is to discuss evolution of such systems from viewpoints of "elements (members) in each system", " interaction between elements" and "theory to describe this interaction".

 ●Course objectives:
General view of “Evolution of life” will be introduced. Then the mechanism of molecular evolution, especially at genomic and DNA level will be described. Human evolution will be reviewed from viewpoints of genetics, adaptation and environmental changes. Mathematical and theoretical biology and animal behavior will also be reviewed with a special reference to the contribution to development of evolutionary understanding of “life”.

●Contents:
1. Tree of life (1/8・9: Mariko Hasegawa)
2. Basis of molecular evolution (1/29: Yoko Satta)
3. Human evolution – genetics, adaptation, and environment - (1/30: Jun Gojobori)
4. Prediction for future - mathematical and theoretical biology - (2/5: Hisashi Ohtsuki)
5. Animal Behaviour – mechanism and evolution - (2/6: Nobuyuki Kutsukake)

●Lecture materials and readings:
No specific textbook is used. References will be introduced in the lecture when necessary.

●Grades:
The grade is determined by reports/homeworks and attendance at the lectures. 60 points are necessary to get the credit.
 
☆For the details of schedule, please refer "Schedule of the classes".
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⇒ Syllabus PDFPDF

8. Molecular Cell BiologyⅡ

【fiscal year 2013】
●Course title
Molecular Cell BiologyⅡ
 
●Credit  
2 credits

● Lecturer(s):
Contacts to the lecturer :
Professor Hiroyuki Araki (NIG C304)
Professor Hironori Niki (NIG R308)
Professor Takehiko Kobayashi (NIG A301)
Professor Kazuhiro Maeshima (NIG G207)
Professor Tatsuo Fukagawa (NIG C208)
Professor Koichi Kawakami (NIG C115)
Associate Professor Emiko Suzuki (NIG G409)
Associate Professor Yasuo Shirakihara, (NIG C110)
Associate Professor Akatsuki Kimura (NIG A321)
Associate Professor Masato Kanemaki (NIG C318)
Associate Professor Shinya Miyagishima (NIG A325)
Associate Professor Daiju Kitagawa (NIG C316)
Professor Mikio Nishimura (NIBB 403)
Professor Yoshikatsu Matsubayashi (NIBB 201)
Associate Professor Shigenori Nonaka (NIBB 464)
Associate Professor Nobuyuki Shiina (NIBB 335)
Assistant Professor Shoji Mano (NIBB 425)
Assistant Professor Kenji Yamada (NIBB 425)
Assistant Professor Yoshiaki Kamada (NIBB 435)
Assistant Professor Kei Nakayama (NIBB 335)
Assistant Professor Hidefumi Shinohara (NIBB 204)
Professor Tetsuro Kokubo (Yokohama City University)

● Time: (oral and TV) 13:30~15:10 on Friday

●Place: (oral and TV) 3F seminar room of the library in National Institute of Genetics  
                                 1F seminar room 4 in National Institute of Basic Biology 

●Prerequisites and Styles:
It is desirable to have the basic knowledge corresponding to the lecture of Molecular and Cellular Biology I, but it is not mandatory. It is given as an oral lecture, which will be provided in English if non-Japanese speaking students attend.

●Contents:
Basic features of molecular and cellular biology will be outlined and discussed. These include regulation of gene expression, protein synthesis and protein degradation, protein structure and function, chromosome structure and dynamics, cell cycle regulation, and cell structure.

●Course objectives:
1. Elucidation of biological phenomena in a molecular level
2. Understanding methods to analyze in a molecular level
3. Elucidation of biological phenomena in a cellular level
4. Understanding methods to analyze in a cellular level

●Schedule:
(Oral and TV) Date [lecturers if omnibus] Topic
May 17          Tetsuro Kokubo, Regulation of Transcription
May 24          Nobuyuki Shiina, Regulation of Translation
May 31          Yasuo Shirakihara, Structure and Function of Protein
June  7          Yoshikatsu Matsubayashi & Hidefumi Shinohara, Posttranslational Modifications
June 21          Kazuhiro Maeshima, Structure of Chromosome
June 28          Masato Kanemaki, Replication of Chromosome
July  5            Koichi Kawakami, Recombination and Repair of Chromosome
July 19           Tatsuo Fukagawa, Partition of Chromosomes
October 25     Daiju Kitagawa, Cell Structure I
November 1    Shinya Miyagishima, Cell Structure II
November 15  Akatsuki Kimura, Cytoskelton
January 17      Mikio Nishimura,Organella Dynamics
January 24      Kenji Yamada, Intracellular Transport
January 31      Yoshiaki Kamada & Kei Nakayama, Signal Transduction
February  7     Shigenori Nonaka, Imaging I
February 14    Shoji Mano, Imaging II
February 21    Occasional date

●Lecture materials and readings:
Molecular Biology of the gene 6th ed., J. D. Watson et al., CSHL Press.
Molecular Biology of the cell 5th ed., B. Alberts et al., Garland Science.
Genes, B. Lewin, Prentice Hall.
Introduction to Genetic Analysis, A. J. F. Griffiths, W H Freeman & Co.
The Cell Cycle, D. Morgan, Oxford University Press.

●Grades:
The grades will be A, B, C, and D, which are determined by the quality of the paper, which must be submitted to the lecturer by the provided deadline. The subject(s) of the paper must be one of the four important aspects that are presented in the above Course Objectives.

●Notes:None

 For the details of schedule, please refer "Schedule of the classes".
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⇒ Syllabus PDFPDF

9. Fundamentals of Biomolecular Science

【fiscal year 2013】
●Course title
Fundamentals of Biomolecular Science
 
●Credit  
2 credits

●Lecturer(s):
Shuji Akiyama
(IMS, Myodaiji campus, Research Facilities, 2F)
Koichi Kato
(IMS, Yamate campus building 3, 3F)
Katsuyuki Nishimura
(IMS, Myodaiji campus, Laboratories room 318)
Yuji Furutani
(IMS, Myodaiji campus, Research Facilities, 3F)

●Schedule
*schedule for the second semester in 2013 10/15, 22, 29, 11/5, 12, 19, 26, (12/3)

Place:    Myodaiji campus, Research Facilities 3F, room 301.
 
●Course objectives:
Core aspects of biophysical chemistry will be overviewed with the life-science student in mind.  This course aims at cultivating the fundamentals necessary to complete the advanced courses of Structural Biomolecular Science and of Functional Biomolecular Science.  The lectures will be given with life-science examples using a textbook (Physical Chemistry: Principles and Applications in Biological Science).
 
●Contents:        
  1. 1.Biological standard state
  2. 2.Chemical equilibrium and its temperature dependence
  3. 3.Kinetics: rates of chemical reactions
  4. 4.Diffusion
  5. 5.Active and passive transport across biological membranes
  6. 6.NMR spectroscopy in structural analyses of biomolecules
  7. 7.UV/vis, CD, and IR spectroscopies in structural analyses of biomolecules
 
●Grades:  Sufficient attendance to the lecture and a score of some reports

☆For the details of schedule, please refer "Schedule of the classes".
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⇒ Syllabus PDFPDF

10. Bioinformatics

【fiscal year 2013】
●Course title
Bioinformatics

●Course objectives
Introduction to informatic principles behind the –omics and their application to analyze gene network, protein network etc. will be lectured.  It is advisable for students to learn the introductory bioinformatic principles.

●Credit  1 (Choose 2 subjects out of 4. (Credit for each subject is 0.5)

●Appropriate grade level and Eligible Departments 1st-5th grades

●Lecturer(s)
Genome Biology (Microorganisms・Plants)
    Hironori Niki(Dept. Genetics R302)
    Keita Aoki(Dept. Genetics R304)
    Tomoya Baba(Dept. Genetics)
    Nori Kurata(Dept. Genetics R111)
    Kenichi Nomura(Dept. Genetics V101)
Systems Biology
    Koichi Kawakami( Dept. Genetics C115)
    Akatsuki Kimura(Dept. Genetics A321)
    Yuji Kohara (Dept. Genetics C709)
Introduction to Mathematical Biology
    Akira Sasaki  (Dept. Evolutionary Studies of Biosystems)
Biological Information Processing
    Kunihiko Sadakane  (Dept. Infomatics)

●Schedule
  For the fiscal year 2013
Genome Biology (Microorganisms・Plants)  (Dept. Genetics ) >Syllabus
   6/10, 17, 7/22, 29  Monday 10:50-12:30
Systems Biology  (Dept. Genetics ) >Syllabus
    1. May 13: Akatsuki Kimura: Overview of systems biology and its approaches.
    2. May 20: Akatsuki Kimura: On the methods of systems biology: focusing on theoretical 
    analyses  and quantitative measurements
    3. May 27: Yuji Kohara: Understanding life as a system: Contributions and perspectives of
    the ‘omics’-approach.
    4. June 3: Koichi Kawakami: Understanding life as a system: From gene function to nervous system.
   
Introduction to Mathematical Biology  (Dept. Evolutionary Studies of Biosystems)  
    10/9, 10
Biological Information Processing (Dept. Infomatics)         
    11/7,14,21,28

 For the details of schedule, please refer "Schedule of the classes".
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⇒ Syllabus PDFPDF

11. Origin of Life

【fiscal year 2013】
●Course title
 Origin of Life

●Course objectives:
Where, when and how the molecules essential for the primitive life were born, how a self-replicating capacity was acquired, how the primitive life evolved to more complex organisms will be broadly discussed.

●Credit   1 

●Appropriate grade level and Eligible Departments 1st-5th grades

●Lecturer(s)
Takashi Gojoubori(Dept. Genetics)
Shinya Miyagishima(Dept. Genetics)
Ken Takai(JAMSTEC) 
Motohide Tamura (The Univ. of Tokyo)
Takeshi Kakegawa (Tohoku Univ.)
Hiroaki Suga (The Univ. of Tokyo)
Hiroyuki Araki(Dept. Genetics)
Toshitaka Fujisawa (CPIS, SOKENDAI)

●Schedule
For the fiscal year 2013
5/22    Evolution of Life  Takashi Gojoubori
6/17    Energy Metabolism: Mitochondria and Chloroplasts  Shinya Miyagishima
10/23  Extremophiles    Ken Takai
10/31  Astrobiology   Motohide Tamura
11/11  Birth of Primitive Life Substances  Takeshi Kakegawa
11/20  The RNA World Hiroaki Suga 
1/16    Replication Phenomenon and its Origin Hiroyuki Araki

For the details of schedule, please refer "Schedule of the classes".
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⇒ Syllabus PDFPDF